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Guinevere Edith van Seenus, born in 1976, is an American model, photographer, and jewelry designer. Born in Brookline, Massachusetts, she was raised in Washington, D.C., and Santa Barbara, California. She is a first-generation American whose parents immigrated to the United States from the Netherlands in the late 1960s.

Van Seenus began modeling at the age of 15 in Southern California. Her career reached A-list status while living in Paris in 1995, marked by her debut cover for Vogue Italia, which was shot by Steven Meisel. The following year, she was nominated for Supermodel of the Year at the VH1 Fashion and Music Awards and was named on Rolling Stone's top ten hot list for the year.

Throughout her career, van Seenus has walked the runways for major fashion houses, including Alexander McQueen, Chanel, Prada, Louis Vuitton, Gucci, Marc Jacobs, Versace, and Comme des Garçons. She has appeared on at least twelve international Vogue covers, including editions in France, Italy, Germany, Japan, and the Netherlands, alongside covers for Harper's Bazaar, W Magazine, Elle, The Face, and Dazed. Additionally, she has appeared in editorials for publications such as American, British, and Italian Vogue, i-D, Numéro, and Allure, and has served as a guest editor for 10 Magazine and Muse Magazine.

In advertising, van Seenus has appeared in campaigns for brands such as Calvin Klein, Giorgio Armani, Miu Miu, Jil Sander, Missoni, H&M, Zara, and the Pirelli Calendar, which featured her twice. She has been photographed by prominent figures including Irving Penn, Richard Avedon, Karl Lagerfeld, Peter Lindbergh, Bruce Weber, and Mario Sorrenti. Beyond modeling, designer Marc Jacobs named the Guinevere Satchel after her, and Pat McGrath LABS named a lipstick shade in her honor. She was also included in the Model as Muse exhibit at the Metropolitan Museum of Art and appeared in the J. Paul Getty Museum's Icons of Style exhibition.

As a photographer, van Seenus uses equipment such as a Leica M6, Leica Minilux, large-format 4x5, Twin-Lens Rolleiflex, 600SE Polaroid, and a Polaroid SX-70. Her photography, which includes self-portraits, has been described as ethereal, and she has shot for Colville, Self-Service magazine, and a Purpose and Perspective cover story. Her special projects include custom art and book collaborations with figures like Rodarte, Catherine Opie, Alec Soth, and Charlotte Dauphin. Her image has been displayed on the exterior of the Metropolitan Museum of Art for the Met Gala and the Louvre Museum for a Yohji Yamamoto exhibit.

Van Seenus actively supports animal rescues and service animal rights. In 2018, she hosted the Fifth Fine Art Photography Benefit Auction for the Humane Society of New York in partnership with the Aperture Foundation. She appeared with her rescue dog, Ashley, in a 2017 Banana Republic campaign and in a profile for The Daily Telegraph. As of September 2019, she was ranked as an Industry Icon on models.com and was represented by DNA Model Management in New York, Next Management in Paris and Milan, and Models 1 in London.